From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal risk
|
| (C;T)
|
2
|
increased response to anesthetics
|
| (T;T)
|
3
|
increased response to anesthetics; 13-20x higher likelihood of red hair
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, known as Arg151Cys or R151C, one of several SNPs in the
MC1R gene associated with red
hair color (
redheads), and in redheaded females, linked to being more responsive to the
anesthetics pentazocine,
nalbuphine, and
butorphanol, often used by dentists [
PMID 9571181,
PMID 12663858,
PMID 18488028]
The risk allele is rs1805007(T), compared with the wild-type rs1805007(C) allele.
The risk allele has also been reported in several studies to be associated with increased risk for melanoma. For example, an odds ratio of 2.94 (CI: 1.04-8.31) has been reported for an Italian population [PMID 16567973], and similarly an odds ratio of 2.9 has been reported for a Polish population [PMID 16988943].
blog about designing melanocortin analogs specific to these genotypes.
See also OMIM 155555.0004
| OMIM | 266300 |
| Desc | SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2; SHEP2 |
| Variant | |
| Related | also |
[PMID 21700618] Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
