Rs662799

rs662799 is a SNP in the APOA5 gene. The rarer rs662799(C) allele has been associated in multiple reports (cited below) to be associated with higher triglyceride levels.

Independently of triglyceride levels, perhaps, a study based on 1,864 Italian patients <45 years old at the time of their first heart attack (myocardial infarction) concluded that this SNP is associated with higher risk for an early heart attack, with a per C allele odds ratio of 1.44 (CI: 1.23-1.69, p = 6.7 × 10(-5)).[PMID 21130994]

This SNP has also been reported to help prevent weight gain from high fat diets.

[PMID 17211608] 1,073 men and 1,207 women participating in the Framingham Offspring Study rs662799 -1131T>C in modulates the effect of fat intake on BMI and obesity risk in both men and women. Individuals with at least one C allele gained significantly less weight on a high fat diet than those homozygous for the T allele.

[PMID 18596051] rs662799 (-1131T>C) influences severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched controls

[PMID 19732897] Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese

[PMID 20395964] Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins

[PMID 20429872] Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

[PMID 20571505] A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

[PMID 20883102] Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients

[PMID 21130994] Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction